Author Archives: Nicholas

Newark Adventures

Just back from a week sequestered in the Newark Hilton, testifying in a patent litigation. More on the trial later, but suffice to say, it has been a real awakening. Lawyers work a lot harder than chemists, I can certainly… Continue reading

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SIMS XVI index now available

There were a number of requests for an index of the proceedings of the Kanazawa meeting. The organizers have gone to a great effort to produce this product. It will be very very useful. The link is either here or… Continue reading

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C60 and Single Cells

Castner, Ratner et al. have just published an important paper that discriminates amongst different cell types at the single cell level. They used C60 etching to remove the overlayer junk from the lawn of cells, and principle component analysis to… Continue reading

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Lipids and SIMS

There is a nice review article (DOI: 10.1021/ac203126f) summarizing many of the most important techniques for characterizing phospholipid films on solid supports. The SIMS technique gets some nice press with the following statement: “Imaging mass spectrometry allows label-free detection of… Continue reading

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More Journal Covers for C60-SIMS

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Fourier Transforms SIMS

There is a thought provoking work published this week resulting from a collaboration between AMOLF in the Netherlands and PNNL where C60-SIMS has been coupled to a high performance FTMS. The mass resolution and accuracy are just what you would… Continue reading

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Imaging Mass Spectrometry

This field really seems to be taking off these days. It is especially interesting to see so many different approaches to the problem. MALDI, DESI, electrospray, fs IR laser desorption, etc etc. There is a big push these days to… Continue reading

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Up and Running

The installation has gone smoothly. Only a few vacuum leaks, a loose circuit board and a loose wire or 2. Gavyn, Andy and Paul have come and gone, so we are on our own now. Our first attempt is the… Continue reading

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October Surprise

What a mess!… Continue reading

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J105 Advances with C60 going..

The first week of activity has gone quite smoothly. A few leaky flanges, and a few stage issues, but the machine is under vacuum, and producing great secondary electron images with less than 300 nm spatial resolution. The vibration isolation… Continue reading

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